Mixed models for repeated measures (MMRM) are a popular choice for analyzing longitudinal continuous outcomes in randomized clinical trials and beyond; see Cnaan, Laird and Slasor (1997) <doi:10.1002/(SICI)1097-0258(19971030)16:20%3C2349::AID-SIM667%3E3.0.CO;2-E> for a tutorial and Mallinckrodt, Lane and Schnell (2008) <doi:10.1177/009286150804200402> for a review. This package implements MMRM based on the marginal linear model without random effects using Template Model Builder ('TMB') which enables fast and robust model fitting. Users can specify a variety of covariance matrices, weight observations, fit models with restricted or standard maximum likelihood inference, perform hypothesis testing with Satterthwaite or Kenward-Roger adjustment, and extract least square means estimates by using 'emmeans'.
| Version: | 0.2.2 |
| Depends: | R (≥ 4.0) |
| Imports: | checkmate (≥ 2.0), lifecycle, methods, nlme, numDeriv, parallel, Rcpp, Rdpack, stats, stringr, TMB (≥ 1.9.1), utils |
| LinkingTo: | Rcpp, RcppEigen, testthat, TMB (≥ 1.9.1) |
| Suggests: | emmeans (≥ 1.6), estimability, knitr, parallelly (≥ 1.32.0), rmarkdown, testthat (≥ 3.0.0), xml2 |
| Published: | 2022-12-20 |
| Author: | Daniel Sabanes Bove [aut, cre], Julia Dedic [aut], Doug Kelkhoff [aut], Kevin Kunzmann [aut], Brian Matthew Lang [aut], Liming Li [aut], Ya Wang [aut], Craig Gower-Page [ctb], Boehringer Ingelheim Ltd. [cph, fnd], Gilead Sciences, Inc. [cph, fnd], F. Hoffmann-La Roche AG [cph, fnd], Merck Sharp & Dohme, Inc. [cph, fnd] |
| Maintainer: | Daniel Sabanes Bove <daniel.sabanes_bove at roche.com> |
| BugReports: | https://github.com/openpharma/mmrm/issues |
| License: | Apache License 2.0 |
| URL: | https://openpharma.github.io/mmrm/ |
| NeedsCompilation: | yes |
| Language: | en-US |
| Materials: | NEWS |
| In views: | MixedModels |
| CRAN checks: | mmrm results |
| Package source: | mmrm_0.2.2.tar.gz |
| Windows binaries: | r-devel: mmrm_0.2.2.zip, r-release: mmrm_0.2.2.zip, r-oldrel: mmrm_0.2.2.zip |
| macOS binaries: | r-release (arm64): mmrm_0.2.2.tgz, r-oldrel (arm64): mmrm_0.2.2.tgz, r-release (x86_64): mmrm_0.2.2.tgz, r-oldrel (x86_64): mmrm_0.2.2.tgz |
| Old sources: | mmrm archive |
| Reverse imports: | rbmi |
| Reverse suggests: | parameters |
Please use the canonical form https://CRAN.R-project.org/package=mmrm to link to this page.