PRSPGx: Construct PGx PRS
Construct pharmacogenomics (PGx) polygenic risk score (PRS) with PRS-PGx-Unadj (unadjusted), PRS-PGx-CT (clumping and thresholding), PRS-PGx-L, -GL, -SGL (penalized regression), PRS-PGx-Bayes (Bayesian regression). Package is based on ”Pharmacogenomics Polyenic Risk Score for Drug Response Prediction Using PRS-PGx Methods” by Zhai, S., Zhang, H., Mehrotra, D.V., and Shen, J., 2021 (submitted).
| Version: |
0.3.0 |
| Depends: |
R (≥ 4.0.0) |
| Imports: |
gglasso (≥ 1.5.0), SGL (≥ 1.3.0), glmnet (≥ 4.0.2), bigsnpr (≥ 1.5.2), Matrix (≥ 1.2.18), GIGrvg (≥ 0.5.0), MCMCpack (≥
1.4.6), bdsmatrix (≥ 1.3.4), bigsparser (≥ 0.4.0), lmtest (≥
0.9.37), mvtnorm (≥ 1.1.0), propagate (≥ 1.0.6), bigparallelr (≥ 0.2.3), methods (≥ 3.6.3), bigstatsr (≥ 1.2.3), Rfast (≥
1.9.9), matrixcalc (≥ 1.0-3) |
| Suggests: |
knitr, rmarkdown |
| Published: |
2022-07-20 |
| Author: |
Song Zhai [aut, cre] |
| Maintainer: |
Song Zhai <zsviolet1993 at gmail.com> |
| License: |
GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| NeedsCompilation: |
yes |
| CRAN checks: |
PRSPGx results |
Documentation:
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