dtpcrm: Dose Transition Pathways for Continual Reassessment Method
Provides the dose transition pathways (DTP) to project in advance
the doses recommended by a model-based design for subsequent patients (stay,
escalate, deescalate or stop early) using all the accumulated toxicity
information; See Yap et al (2017) <doi:10.1158/1078-0432.CCR-17-0582>. DTP
can be used as a design and an operational tool and can be displayed as a
table or flow diagram. The 'dtpcrm' package also provides the modified
continual reassessment method (CRM) and time-to-event CRM (TITE-CRM) with
added practical considerations to allow stopping early when there is
sufficient evidence that the lowest dose is too toxic and/or there is a
sufficient number of patients dosed at the maximum tolerated dose.
| Version: |
0.1.1 |
| Imports: |
diagram, dfcrm |
| Suggests: |
knitr, rmarkdown, testthat |
| Published: |
2019-08-20 |
| Author: |
Christina Yap [aut, cre],
Daniel Slade [aut],
Kristian Brock [aut],
Yi Pan [aut] |
| Maintainer: |
Christina Yap <yapchristina17 at gmail.com> |
| License: |
GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| NeedsCompilation: |
no |
| CRAN checks: |
dtpcrm results |
Documentation:
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